GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs4888262 | 1 | rs7201320 | chr16:74694058 | RFWD3 | chr16:74655298-74700779:- | -0.22 | -4.79 | 6.03E-6 | Testicular germ cell tumor |
| THYM | cis | rs8050907 | 1 | rs7206416 | chr16:4626724 | NMRAL1 | chr16:4511696-4526307:- | -0.47 | -5.54 | 2.74E-7 | Obesity-related traits |
| THYM | cis | rs9894429 | 1 | rs7209180 | chr17:79581519 | TSPAN10 | chr17:79609349-79615778:+ | 0.63 | 6.68 | 1.61E-9 | Eye color traits |
| THYM | cis | rs7223966 | 1 | rs7209435 | chr17:61712964 | TCAM1P | chr17:61934376-61941738:+ | -0.53 | -4.38 | 3.02E-5 | Body mass index |
| THYM | cis | rs7223966 | 1 | rs7211213 | chr17:61769456 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.4 | 2.85E-5 | Body mass index |
| THYM | cis | rs9902453 | 1 | rs7212497 | chr17:28335949 | EFCAB5 | chr17:28256874-28435469:+ | -0.31 | -4.25 | 5.04E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs9894429 | 1 | rs7213129 | chr17:79581573 | TSPAN10 | chr17:79609349-79615778:+ | 0.63 | 6.68 | 1.61E-9 | Eye color traits |
| THYM | cis | rs8078723 | 1 | rs7214085 | chr17:38169095 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -9.52 | 1.73E-15 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs7223966 | 1 | rs7216798 | chr17:61740963 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.47 | 2.2E-5 | Body mass index |
| THYM | cis | rs7221109 | 1 | rs7221109 | chr17:38770286 | SMARCE1 | chr17:38783976-38804103:- | -0.28 | -4.46 | 2.28E-5 | Type 1 diabetes |
| THYM | cis | rs9894429 | 1 | rs7222241 | chr17:79574714 | TSPAN10 | chr17:79609349-79615778:+ | 0.63 | 6.68 | 1.61E-9 | Eye color traits |
| THYM | cis | rs9902453 | 1 | rs7222308 | chr17:28277041 | EFCAB5 | chr17:28256874-28435469:+ | 0.32 | 4.3 | 4.2E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs9894429 | 1 | rs7223613 | chr17:79574803 | TSPAN10 | chr17:79609349-79615778:+ | -0.63 | -6.68 | 1.61E-9 | Eye color traits |
| THYM | cis | rs7223966 | 1 | rs7223672 | chr17:61720565 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.33 | 3.63E-5 | Body mass index |
| THYM | cis | rs9902453 | 1 | rs7223786 | chr17:28332107 | EFCAB5 | chr17:28256874-28435469:+ | -0.31 | -4.25 | 5.04E-5 | Coffee consumption (cups per day) |